La farmacéutica AbbVie está expandiendo su portafolio con la compra de Nimble Therapeutics. La adquisición incluye el elemento más importante de su cartera: n inhibidor oral de péptidos IL23R en etapa de desarrollo preclínico para la psoriasis, además de una prometedora cartera de candidatos de péptidos orales con posibilidades de aplicación en múltiples enfermedades autoinmunes.
Como parte de la compra, Nimble Therapeutics también cederá a AbbVie su innovadora plataforma de creación, cribado y perfeccionamiento de péptidos, una tecnología exclusiva que acelera la identificación y optimización de nuevos objetivos terapéuticos.
“La incorporación de la cartera de Nimble a la ya existente de AbbVie, combinada con nuestra profunda experiencia clínica y traslacional en inmunología, representa una importante oportunidad de crecimiento”, afirmó Jonathon Sedgwick, Ph.D., vicepresidente senior y director global de investigación en descubrimiento de AbbVie. “Juntos, AbbVie y Nimble tienen el potencial de abordar la significativa necesidad médica no cubierta de las personas que viven con enfermedades autoinmunes”. Las declaraciones se conocieron en el comunicado oficial entregado por la compañía.
Entre los desarrollos más prometedores de Nimble destaca una terapia oral que inhibe la proteína IL-23, el mismo objetivo que Skyrizi, el exitoso tratamiento inyectable de AbbVie. Este medicamento se encuentra en la etapa preclínica, al igual que otros dos candidatos destinados a tratar la miastenia grave generalizada y la enfermedad inflamatoria intestinal.
La adquisición de Nimble por parte de AbbVie es el tercer movimiento de la compañía este año en el campo de los desarrolladores de terapias inmunológicas. Estas adquisiciones buscan fortalecer su portafolio de productos en inmunología y capitalizar la creciente inversión en medicamentos que regulen la hiperactividad del sistema inmunológico responsable de enfermedades como la psoriasis y la enfermedad inflamatoria intestinal. La innovación clave del principal candidato de Nimble radica en su formulación oral, diferenciándose de terapias como Skyrizi de AbbVie, Tremfya de Johnson & Johnson y Omvoh de Eli Lilly, que requieren administración mediante inyecciones.
El camino de Nimble Therapeutics en la industria farmacéutica
En 2019, Nimble Therapeutics comenzó a operar como una compañía independiente dentro de la farmaindustria. Inicialmente, se enfocó en la comercialización de su tecnología exclusiva de síntesis química para el desarrollo de medicamentos. El CEO de Nimble Therapeutics, junto con otros altos ejecutivos de la compañía, cuenta con una sólida experiencia en Roche, organización con la que mantienen colaboraciones en investigaciones científicas.
Según el acuerdo alcanzado con AbbVie, además del pago inicial, la empresa se comprometió a realizar “pagos provisionales de financiación” y un monto adicional vinculado al progreso de los proyectos en desarrollo, lo que destaca la importancia de estas investigaciones.
Dentro del portafolio de Nimble, se incluyen un fármaco oral orientado a bloquear la señalización “C5” para tratar la miastenia gravis generalizada y otro que actúa como inhibidor de la proteína TL1A, ambos con aplicaciones innovadoras en el manejo de enfermedades autoinmunes.
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