Investigadores de la Universidad de Florida (UF, Gainesville, EE. UU.), La Universidad de Michigan (UM; Ann Arbor, EE. UU.) Y otras instituciones, realizaron un estudio internacional en 17 centros de resonancia magnética en Austria, Alemania y EE. UU. donde involucraron a 1.002 pacientes para desarrollar y validar un sistema automatizado que diagnostique con precisión la enfermedad de Parkinson (EP) y otros trastornos neurodegenerativos relacionados.
Por consiguiente, los investigadores utilizaron 60 regiones y áreas de interés de plantilla para enseñar a un algoritmo de aprendizaje automático (ML) la diferencia entre la EP, el parkinsonismo atípico (es decir, la atrofia del sistema múltiple y la parálisis supranuclear progresiva), la atrofia del sistema múltiple y la parálisis supranuclear progresiva.
hallazgos del estudio
Los resultados revelaron que una combinación de resonancia magnética ponderada por difusión y el rango de la III Escala de Clasificación de la Enfermedad de Parkinson Unificada de la Sociedad de Trastornos del Movimiento (MDS-UPDRS III) es capaz de diferenciar formas de Parkinson.
De ahí que, las 10 regiones con mayor importancia relativa para el modelo fueron aquellas previamente demostradas como patológicamente involucradas en EP, atrofia multisistémica y parálisis supranuclear progresiva. Los investigadores también desarrollaron una plantilla de región de interés y tres plantillas de tractografía de materia blanca.
También puede ver: Sobre la depuración de las EPS en el país – Videocolumna de CONSULTORSALUD
reducción de casos mal diagnosticados
Finalmente, los investigadores concluyeron “Nuestro método puede ayudar a reducir la cantidad de casos mal diagnosticados en el futuro. Dado que estas enfermedades requieren planes de tratamiento únicos y diferentes medicamentos, y los ensayos clínicos que prueban nuevos medicamentos requieren el diagnóstico correcto, hacer lo correcto es importante para la atención al paciente “. así mismo, indicaron “el método de MRI ponderado por difusión no involucra trazadores radiactivos, está completamente automatizado y se puede recolectar en menos de 12 minutos en escáneres de MRI 3T en todo el mundo”.
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