Según la OMS, la esquizofrenia es la novena causa de años perdidos por discapacidad para las personas entre los 15 y 44 años de edad, como del deterioro en la calidad de vida y el aumento en el uso de los servicios de salud y de costos asociados.
La esquizofrenia es un trastorno mental grave e incapacitante cuyo inicio, en la mayoría de los casos, se da en la adolescencia o adultez temprana, lo que lleva a que una gran proporción de estos pacientes no logre desarrollarse personal o profesionalmente, son muchas veces incapaces de vivir independientes y tener una vida productiva.
Entre los factores de riesgo asociados a esquizofrenia se incluyen: historia familiar, padre mayor de 60 años, microdeleciones del cromosoma 22q11 o síndrome velocardiofacial, exposición prenatal a hambruna, exposición prenatal a infecciones como toxoplasmosis, rubeola o influenza, estrés materno, incompatibilidad Rh, complicaciones del embarazo o el parto, el consumo de cannabis durante la adolescencia o la migración.
Nuevos factores de riesgo descritos son: el coeficiente intelectual bajo (reportándose hasta cinco veces más riesgo de esquizofrenia en personas con coeficiente intelectual menor de 70), el ser fumador debido a modulación de mecanismos genéticos, el trauma craneoencefálico.
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