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Boehringer Ingelheim avanza lentamente hacia la construcción de una cartera de productos oncológicos
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Boehringer Ingelheim es uno de los pocos gigantes farmacéuticos que no tiene una cartera amplia para oncología, un campo que ha tratado de descifrar durante muchos años. La farmacéutica alemana continúa comprometida con la innovación de inhibidores de Kras, pero los resultados de estos ensayos estarán solamente disponibles en 2023.
No obstante, el desarrollo oncológico más avanzado de Boehringer no es un inhibidor de Kras sino un antagonista de MDM2-p53 denominado BI 907828 que comenzó a probarse en liposarcomas, sin embargo, aún si el medicamento se aprobara sin ningún contratiempo, llegaría al mercado hasta el 2024. Es preciso decir, que la gigante alemana ya ha comercializado medicamentos oncológicos como Vargatef y Gilotrif aunque no han tenido grandes proyecciones de ventas en el mercado.
Además del cáncer, la compañía busca abrirse un espacio en el mercado de la fibrosis pulmonar idiopática, mediante su proyecto BI 1015550, los datos de este ensayo de fase II se presentarán el próximo 16 de mayo, aunque los voceros internacionales de la empresa han revelado que los resultados son prometedores.
Tanto así que el ensayo de fase III comenzará también este año, de hecho se probará el medicamento en monoterapia y en combinación con otro medicamentos IPF ya existentes, como el Ofev de la misma compañía y el esbriet de Roche.
Ofev no es un modificador de la enfermedad, sin embargo, pese a que no cubre totalmente las necesidades de los pacientes, sigue siendo el segundo fármaco más importante de la compañía con ventas en 2021 de más de $2.700 millones de dólares.
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El medicamento más vendido de la compañía es Jardiance que desarrolló en conjunto con Eli Lilly y cuya ampliación de etiqueta va más allá de la Diabetes Mellitus. De hecho, Jardiance recibió aprobación de la FDA hace unos meses para tratar la insuficiencia cardíaca con un perfil prometedor para tratar también la Enfermedad Renal Crónica (el estudio Empa-Kidney se detuvo antes de tiempo por su eficacia).
En este segmento tiene un competidor directo y con muy buenos resultados para todas las indicaciones que Boehringer hasta ahora esta buscando, se trata de Farxiga de AstraZeneca.
En un futuro más cercano Boehringer buscará la aprobación del inhibidor de IL-36, spesolimab desarrollado para tratar los brotes de psoriasis pustulosa generalizada. Pero, esta es una enfermedad muy rara por lo que la compañía buscará ampliar su uso para hidradenitis supurativa y enfermedad de Crohn; dos usos para los que ya está siendo probado.
Estos son los desarrollos destacados de Boehringer Ingelheim
| Proyecto | Descripción | Estado, detalles del ensayo |
| espesolimab | MAb anti-IL-36 | A la espera de la decisión de la FDA sobre brotes de GPP; ph2 en hidradenitis supurativa y enfermedad de Crohn con fístulas u obstrucción intestinal |
| BI 1015550 | inhibidor de PDE4B | Los datos de Ph2 se presentarán en ATS en mayo de 2022 |
| BI 907828 | Antagonista de MDM2-p53 | Pivotal ph2/3 en liposarcoma se completa en marzo de 2024 |
| BI 1701963 | Inhibidor de Sos1 (Kras) | Ph1 Krystal-14 + adagrasib de Mirati; ph1 + BI 1823911 |
| BI 1823911 | Inhibidor selectivo de Kras G12C | Ph1 + BI 1701963 |
| Effi-dem (BI 765063/OSE-172)* | MAb anti-SIRPα | Ph1 ( NCT03990233 & NCT05068102 ) + BI 754091 (inhibidor de PD-1) en tumores sólidos; ph1 + BI 754091 + BI 836880 (anti-VEGF/Ang2) en cánceres de cabeza y cuello/hígado |
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